[dba-VB] Web colours

Hi all

Those of you designing web pages, do you still stick to the "safe web colours" - the limited selection of 216 colours out of 256 possible colours?

  http://www.lynda.com/hex.asp 

As this Lynda writes, in 1996 this might be a concern, but today where I hardly know nobody having the old 65000 colour resolution, is this still valid in any way?
Isn't is safe - at least for normal business use - to just go ahead and use the full RGB scale?

/gustav