[AccessD] "Rule of Thumb" for size of Access "Accdb" file (Front End)

Are there any general rules for how large an Access 2007 "Accdb" file
can be?

This would be the "Front End" part of an Access Application, with the
data stored in the "Back End".

If necessary, we could split the Front End into more than one Accdb
file.

Thanks,
Brad