[dba-Tech] Lost my CD-Rom

I can't access CD files -- it's just gone. It's not showing up in Internet
Explorer. That means I can't even repair Windows, because the system won't
read the repair CD. 
 
Any help? I don't have a clue where to start looking. 
 
Yes, I've rebooted several times. I've also run all my virus/spyware/adware
scans and even ran through housecall at Trends Micro. 
 
Susan H.