[dba-Tech] Desktop Trashed?

Hi All,
Sorry for the double post but I know Some don't subscribe to both.  Our
desktop, main PC, went out to lunch after my son did something...who knows.
I know Trojan, worms and whatnot were downloadded.  I spent the better part
of 14 hours trying to get it back to normal...no luck.  I downloaded
ZoftSpySE, CyberDefender, T-R Trogran Remover 6.7.5 but no cigar.  Ran these
in windows, safe mode and no-safe mode.  The system just crawls, cpu rarely
goes over 1-3%.  Do I have to reformat the disk and loose everything or is
there a solution I missing.  This is a royal pain in the a**, especially
after running the system for 3 years without a hitch,  Running AVG, Spy
Sweeper, PC Tools Dr.....also have Adaware and Spybot on the PC.  I suppose
I could get all the files I need off in safe mode but if there is a way to
systematically get this working again without losing files, that would be
great.  I thought there was someone who had a similar problem...but maybe
that was at work.  Any suggestions GREATLY appreciated.
MTIA
ED